A factor that distinguishes patients with antiphospholipid syndrome (APS) and Type 2 diabetes is both have reduced nitric oxide bioavailability. Both diseases impair the absorption of nitric oxide which is naturally produced within the endothelial cells of the vasculature. The role of l-arginine and l-citrulline supplementation found in L-arginine plus helps restore normal nitric oxide levels according to Science Direct here.
APS is a disorder of the immune system that increases the risk of developing conditions such as deep vein thrombosis. The ‘interactions between circulating aPL and cell surface molecules of target cells, primarily endothelial cells and platelets, underlie the vascular disease phenotypes of APS’ increase the risk of blood clot according to research by C Mineo. The article goes onto discuss the beneficial role that l-arginine can play.
Type 2 Diabetes
Similarly a study published by the International Journal of Endocrinology carried out on rats showed that ‘type II diabetes mellitus (T2DM) decreases both the production and bioavailability of nitric oxide (NO)’. Rats treated with l-arginine had a delay in ‘the onset of insulin resistance and renal dysfunction’.
L-arginine increases nitric oxide production and is beneficial in these two diseases and in which they are a factor. As with all natural supplements seek advice from your doctor first*.
L-arginine plus is now available to purchase in the UK found here